Spatiotemporal pattern recognition and dynamical analysis of COVID-19 in Shanghai, ChinaArticle Published on 2022-12-072022-11-15 Journal: Journal of theoretical biology [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] Analysis Autocorrelation analysis China COVID-19 COVID-19 disease Daily Daily reproduction number diffusion disease dissemination dynamic Dynamic model early stage Effect hotspot IMPROVE mutant omicron outbreak provided retrospective SARS-CoV-2 transmission Shanghai Spatial statistics. spatiotemporal statistical suffered suppress the epidemic [DOI] 10.1016/j.jtbi.2022.111279 PMC 바로가기
SARS-CoV-2 fusion-inhibitory lipopeptides maintain high potency against divergent variants of concern including OmicronSARS-CoV-2 융합 억제 리포펩티드는 오미크론을 포함한 다양한 관심 변종에 대해 높은 효능을 유지합니다Article Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 변종, 치료제, [키워드] activity Alpha antiviral activity Beta broad-spectrum antiviral broad-spectrum antivirals Cell Cell fusion cell-cell fusion combating COVID-19 pandemic D614G Delta drugs effective vaccine Effective vaccines exhibited FIVE fusion inhibitor Gamma Impact Infection inhibiting inhibitor inhibitors Lambda lipopeptide maintain mutant omicron Omicron variant other variant other variants outbreak pseudovirus pseudovirus pseudovirus infection pseudoviruses reduced S protein S proteins SARS-CoV-2 significantly the S protein therapeutic variant variants variants of concern variants of concern. VoC VOCs wild-type WT virus [DOI] 10.1080/22221751.2022.2098060 PMC 바로가기 [Article Type] Article
Hotspot residues and resistance mutations in the nirmatrelvir-binding site of SARS-CoV-2 main protease: Design, identification, and correlation with globally circulating viral genomesArticle Published on 2022-11-122022-11-15 Journal: Biochemical and Biophysical Research Communication [Category] SARS, 변종, 치료제, [키워드] acute respiratory syndrome Adaptability Antiviral approved circulating coronavirus correlation COVID-19 cases COVID-19 pandemic develop drug resistance FDA highest hotspot intracellular protein Like M pro main protease Mild-to-moderate mutant Mutation mutations Nirmatrelvir offer omicron predicted Probability protease Protein design reported residue residues resistance resistance mutations robust SARS-CoV-2 SARS-CoV-2 lineage signature Signatures of adaptation. Surveillance unique variant Variation variations viral adaptation viral genome viruses [DOI] 10.1016/j.bbrc.2022.09.010 PMC 바로가기
Wastewater surveillance allows early detection of SARS-CoV-2 omicron in North Rhine-Westphalia, GermanyArticle Published on 2022-11-102022-11-15 Journal: The Science of the total environment [Category] COVID19(2023년), SARS, 변종, 치료기술, [키워드] Analysis approach close monitoring collected COVID-19 COVID-19 surveillance demonstrated detection Detection workflow dominant variant Epidemiology evaluate fraction Germany identify Initially K417N Laboratory Local MONITOR mutant Mutation N501Y NGS North omicron Omicron, B.1.1.529 PCR primer public health purified Regulation required resulting RT-qPCR SARS-CoV-2 SARS-CoV-2 epidemiology SARS-CoV-2 monitoring SARS-CoV-2 RNA SARS-CoV-2 variant Sequencing state subsequent Support Surveillance Treatment variant variant of concern was performed wastewater Wastewater-based epidemiology (WBE). [DOI] 10.1016/j.scitotenv.2022.157375 PMC 바로가기
Fully Automated CRISPR-LAMP Platform for SARS-CoV-2 Delta and Omicron VariantsArticle Published on 2022-11-082022-11-15 Journal: Analytical Chemistry [Category] COVID19(2023년), SARS, 변종, 치료기술, 치료제, [키워드] 95% confidence interval Accuracy amplification automated B.1.617.2 Combined CRISPR D614G Delta detect Detection limit diagnostic diagnostic systems IMPROVE limit mutant mutations omicron P681H P681R platform Point mutation RdRP reaction RNA SARS-CoV-2 SARS-CoV-2 strain sensitivity Sensitivity and specificity specificity spike stability T478K variants wild type [DOI] 10.1021/acs.analchem.2c03607 PMC 바로가기
Lineage abundance estimation for SARS-CoV-2 in wastewater using transcriptome quantification techniquesArticle Published on 2022-11-082022-11-16 Journal: Genome Biology [Category] SARS, 변종, 유전자 메커니즘, [키워드] Algorithm can be used clinical samples effort high variability Lineage MONITOR mutant pandemic Prevalence quantification SARS-CoV-2 SARS-CoV-2 mutant SARS-CoV-2 RNA Sequencing Spread Surveillance Transcriptome [DOI] 10.1186/s13059-022-02805-9 PMC 바로가기
The DEAD box RNA helicase DDX42 is an intrinsic inhibitor of positive-strand RNA virusesArticle Published on 2022-11-072022-11-16 Journal: EMBO Reports [Category] SARS, 변종, [키워드] Antiviral approach cell line Complexes CRISPR DDX42 DDX42 DEAD-box RNA helicase Depletion DNA dominant-negative elements expression Helicase HIV-1 HIV-1 infection identify immunoprecipitation in vitro increase Infection inhibit inhibitor Interaction intrinsic intrinsic immunity LINE-1 mutant overexpression Perspective primary cells Replication restrict reverse transcription ribonucleoprotein RNA RNA virus RNA viruses RNA-seq analysis SARS-CoV-2 target cells viral infections viral inhibition. viruses [DOI] 10.15252/embr.202154061 PMC 바로가기
In silico characterization of mutations circulating in SARS-CoV-2 structural proteinsArticle Published on 2022-11-012022-11-16 Journal: Journal of biomolecular structure & dynamics [Category] SARS, 변종, [키워드] Algorithm Analysis caused circulating computational approach computational tool COVID-19 D614G death Deleterious discrete molecular dynamics DMD envelope protein full-length identify infections meta-data molecular molecular simulations mutant Mutation mutations N protein Neutral NMA non-structural protein normal mode analysis Nsp3 nucleocapsid nucleocapsid protein pandemic predicted Protein protein coding gene protein stability Proteins RdRP RNA-directed RNA polymerase SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 genomes sequence Seven Spike protein stability structural protein suggested utilised viral dynamics viral genome viral pathogenicity Viral pathogenicity. [DOI] 10.1080/07391102.2021.1908170 PMC 바로가기
Identification and assessment of TCR-T cells targeting an epitope conserved in SARS-CoV-2 variants for the treatment of COVID-19Article Published on 2022-11-012022-11-15 Journal: International immunopharmacology [Category] SARS, 변종, 진단, [키워드] acute respiratory syndrome anti-inflammatory cytokine CD4 CD8 Cell Cell-based therapy conserved Conserved T cell epitope Coronavirinae coronavirus coronavirus Coronavirus disease 2019 Coverage COVID-19 COVID-19 in patients current epitope global public health help highlight Human identification Immunity infect Infection Inflammatory monoclonal antibody mutant new SARS-CoV-2 omicron outbreak pandemic PROTECT Protein RdRP restrict RNA-dependent RNA polymerase SARS-CoV-2 SARS-CoV-2 replication SARS-CoV-2 variant SARS-CoV-2 variants secreted Seven specificity T cell T cells targeted epitope TCR TCR-T therapy. therapy transducing Treatment unique Vaccine variant variants [DOI] 10.1016/j.intimp.2022.109283 PMC 바로가기
Challenges of vaccination and herd immunity in COVID-19 and management strategiesArticle Published on 2022-11-012022-11-16 Journal: The clinical respiratory journal [Category] SARS, 변종, [키워드] acute respiratory syndrome caused challenge contagious coronavirus Coronavirus disease 2019 country COVID-19 COVID-19 vaccination COVID-19 vaccine Critical death Defense effective eligible help herd immunity Hospitalization Immunity management mutant Outbreaks prevention PROTECT reduce reducing risk SARS-CoV-2 SARS-CoV-2 variant severe disease Spread susceptible the disease vaccination vaccination. variants viral disease virus [DOI] 10.1111/crj.13543 PMC 바로가기